BDBM50159110 1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piperidine::1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine::1-[3-(4-hexahydro-1-pyridinylmethylphenoxy)propyl]hexahydropyridine::1-[4-(3-hexahydro-1-pyridinylpropoxy)benzyl]hexahydropyridine::CHEMBL129542::JNJ-5207852
SMILES C(COc1ccc(CN2CCCCC2)cc1)CN1CCCCC1
InChI Key InChIKey=PTKHFRNHJULJKT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 50159110
Affinity DataKi: 0.0603nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Antagonist potency against human H3 receptor in GTPgamma[S]-AssayMore data for this Ligand-Target Pair
Affinity DataKi: 0.209nMAssay Description:Displacement of [3H]UR-P1294 from human H3R receptor expressed in HEK293 cells by radioligand competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.275nMAssay Description:Binding affinity to human H3RMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.570nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.575nMAssay Description:Binding affinity to human recombinant histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 0.580nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Binding affinity to Homo sapiens (human) H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Inverse agonist activity at human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cells after 1 hr by fluid scintillation co...More data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.630nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 0.631nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Antagonist activity at human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293T cells by NanoBRET binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Displacement of [125I]iodoproxyfan from human recombinant histamine H3 receptor expressed in human SK-N-MC cellsMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Displacement of N-[3H]methylhistamine from rat histamine H3 receptor in rat cortical hemispheresMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 1.26nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKi: 1.26nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 9.24nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Inhibition of histone H3 receptorMore data for this Ligand-Target Pair